Parthenolide inhibits nociception and neurogenic vasodilatation in the trigeminovascular system by targeting TRPA1 channel

While feverfew has been used for centuries to treat pain and headaches and is recommended for migraine treatment, the mechanism for its protective action remains unknown. Migraine is triggered by calcitonin gene-related peptide (CGRP) release from trigeminal neurons. Peptidergic sensory neurons, exp...

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Main Authors: Materazzi, Serena, Benemei, Silvia, Fusi, Camilla, Gualdani, Roberta, De Siena, Gaetano, Vastani, Nisha, Andersson, David A., Trevisan, Gabriela, Moncelli, Maria Rosa, Wei, Xiaomei, Dussor, Gregory, Pollastro, Federica, Patacchini, Riccardo, Appendino, Giovanni, Geppetti, Pierangelo, Nassini, Romina
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3843982/
https://ncbi.nlm.nih.gov/pubmed/23933184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pain.2013.08.002
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