Overcoming IGF1R/IR Resistance Through Inhibition of MEK Signaling in Colorectal Cancer Models

PURPOSE: Results from clinical trials involving resistance to molecularly targeted therapies have revealed the importance of rational single agent and combination treatment strategies. In this study, we tested the efficacy of a type 1 insulin-like growth factor receptor (IGF1R)/insulin receptor (IR)...

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Bibliographic Details
Main Authors: Flanigan, Sara A., Pitts, Todd M., Newton, Timothy P., Kulikowski, Gillian N., Tan, Aik Choon, McManus, Martine C., Spreafico, Anna, Kachaeva, Maria I., Selby, Heather M., Tentler, John J., Eckhardt, S. Gail, Leong, Stephen
Format: Artigo
Language:Inglês
Published: 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3843359/
https://ncbi.nlm.nih.gov/pubmed/24045180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-0145
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