Serum IGF-1 is insufficient to restore skeletal size in the total absence of the growth hormone receptor

States of growth hormone (GH) resistance, such those observed in Laron’s dwarf patients, are characterized by mutations in the GH receptor (GHR), decreased serum and tissue IGF-1 levels, impaired glucose tolerance, and impaired skeletal acquisition. IGF-1 replacement therapy in such patients increas...

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Bibliografiske detaljer
Main Authors: Wu, Yingjie, Sun, Hui, Basta-Pljakic, Jelena, Cardoso, Luis, Kennedy, Oran D, Jasper, Hector, Domené, Horacio, Karabatas, Liliana, Guida, Clara, Schaffler, Mitchell B, Rosen, Clifford J, Yakar, Shoshana
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3843230/
https://ncbi.nlm.nih.gov/pubmed/23456957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.1920
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