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Low levels of plasma IGF-1 inhibit intracortical bone remodeling during aging

Studies linking insulin-like growth factor-1 (IGF-1) to age-related bone loss in humans have been reported but remain only correlative. In this investigation, we characterized the bone phenotype of aged WT C57BL/6J male mice in comparison to that of C57BL/6J mice with reduced serum IGF-1 levels aris...

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Detalhes bibliográficos
Main Authors: Courtland, Hayden-William, Kennedy, Oran D., Wu, Yingjie, Gao, Ying, Sun, Hui, Schaffler, Mitchell B., Yakar, Shoshana
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Netherlands 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3776121/
https://ncbi.nlm.nih.gov/pubmed/22976122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11357-012-9469-8
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