Serum IGF-1 is insufficient to restore skeletal size in the total absence of the growth hormone receptor

States of growth hormone (GH) resistance, such those observed in Laron’s dwarf patients, are characterized by mutations in the GH receptor (GHR), decreased serum and tissue IGF-1 levels, impaired glucose tolerance, and impaired skeletal acquisition. IGF-1 replacement therapy in such patients increas...

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Bibliografische gegevens
Hoofdauteurs: Wu, Yingjie, Sun, Hui, Basta-Pljakic, Jelena, Cardoso, Luis, Kennedy, Oran D, Jasper, Hector, Domené, Horacio, Karabatas, Liliana, Guida, Clara, Schaffler, Mitchell B, Rosen, Clifford J, Yakar, Shoshana
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2013
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3843230/
https://ncbi.nlm.nih.gov/pubmed/23456957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.1920
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