Serum IGF-1 is insufficient to restore skeletal size in the total absence of the growth hormone receptor

States of growth hormone (GH) resistance, such those observed in Laron’s dwarf patients, are characterized by mutations in the GH receptor (GHR), decreased serum and tissue IGF-1 levels, impaired glucose tolerance, and impaired skeletal acquisition. IGF-1 replacement therapy in such patients increas...

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Detalhes bibliográficos
Main Authors: Wu, Yingjie, Sun, Hui, Basta-Pljakic, Jelena, Cardoso, Luis, Kennedy, Oran D, Jasper, Hector, Domené, Horacio, Karabatas, Liliana, Guida, Clara, Schaffler, Mitchell B, Rosen, Clifford J, Yakar, Shoshana
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3843230/
https://ncbi.nlm.nih.gov/pubmed/23456957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.1920
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