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Serum IGF-1 is insufficient to restore skeletal size in the total absence of the growth hormone receptor
States of growth hormone (GH) resistance, such those observed in Laron’s dwarf patients, are characterized by mutations in the GH receptor (GHR), decreased serum and tissue IGF-1 levels, impaired glucose tolerance, and impaired skeletal acquisition. IGF-1 replacement therapy in such patients increas...
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| Autors principals: | , , , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3843230/ https://ncbi.nlm.nih.gov/pubmed/23456957 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.1920 |
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