DMP-1-mediated Ghr gene recombination compromises skeletal development and impairs skeletal response to intermittent PTH

Bone minerals are acquired during growth and are key determinants of adult skeletal health. During puberty, the serum levels of growth hormone (GH) and its downstream effector IGF-1 increase and play critical roles in bone acquisition. The goal of the current study was to determine how bone cells in...

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Библиографические подробности
Опубликовано в: :FASEB J
Главные авторы: Liu, Zhongbo, Kennedy, Oran D., Cardoso, Luis, Basta-Pljakic, Jelena, Partridge, Nicola C., Schaffler, Mitchell B., Rosen, Clifford J., Yakar, Shoshana
Формат: Artigo
Язык:Inglês
Опубликовано: Federation of American Societies for Experimental Biology 2016
Предметы:
Research Communication
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4714547/
https://ncbi.nlm.nih.gov/pubmed/26481310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.15-275859
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