Arf-like GTPase Arl8b regulates lytic granule polarization and natural killer cell–mediated cytotoxicity

Natural killer (NK) lymphocytes contain lysosome-related organelles (LROs), known as lytic granules, which upon formation of immune synapse with the target cell, polarize toward the immune synapse to deliver their contents to the target cell membrane. Here, we identify a small GTP-binding protein, A...

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Hauptverfasser: Tuli, Amit, Thiery, Jerome, James, Ashley M., Michelet, Xavier, Sharma, Mahak, Garg, Salil, Sanborn, Keri B., Orange, Jordan S., Lieberman, Judy, Brenner, Michael B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Cell Biology 2013
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3842998/
https://ncbi.nlm.nih.gov/pubmed/24088571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E13-05-0259
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