Cholesterol Defect Is Marked across Multiple Rodent Models of Huntington's Disease and Is Manifest in Astrocytes

Brain cholesterol, which is synthesized locally, is a major component of myelin and cell membranes and participates in neuronal functions, such as membrane trafficking, signal transduction, neurotransmitter release, and synaptogenesis. Here we show that brain cholesterol biosynthesis is reduced in m...

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Autores principales: Valenza, Marta, Leoni, Valerio, Karasinska, Joanna M., Petricca, Lara, Fan, Jianjia, Carroll, Jeffrey, Pouladi, Mahmoud A., Fossale, Elisa, Nguyen, Huu Phuc, Riess, Olaf, MacDonald, Marcy, Wellington, Cheryl, DiDonato, Stefano, Hayden, Michael, Cattaneo, Elena
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for Neuroscience 2010
Materias:
Brief Communications
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3842469/
https://ncbi.nlm.nih.gov/pubmed/20702713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0917-10.2010
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