Disruption of astrocyte-neuron cholesterol cross talk affects neuronal function in Huntington's disease

In the adult brain, neurons require local cholesterol production, which is supplied by astrocytes through apoE-containing lipoproteins. In Huntington's disease (HD), such cholesterol biosynthesis in the brain is severely reduced. Here we show that this defect, occurring in astrocytes, is detrim...

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Bibliographic Details
Published in:Cell Death Differ
Main Authors: Valenza, M, Marullo, M, Di Paolo, E, Cesana, E, Zuccato, C, Biella, G, Cattaneo, E
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2015
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Original Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4356339/
https://ncbi.nlm.nih.gov/pubmed/25301063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2014.162
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