ATR–Chk1–APC/C(Cdh1)-dependent stabilization of Cdc7–ASK (Dbf4) kinase is required for DNA lesion bypass under replication stress

Cdc7 kinase regulates DNA replication. However, its role in DNA repair and recombination is poorly understood. Here we describe a pathway that stabilizes the human Cdc7–ASK (activator of S-phase kinase; also called Dbf4), its regulation, and its function in cellular responses to compromised DNA repl...

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Détails bibliographiques
Auteurs principaux: Yamada, Masayuki, Watanabe, Kenji, Mistrik, Martin, Vesela, Eva, Protivankova, Iva, Mailand, Niels, Lee, MyungHee, Masai, Hisao, Lukas, Jiri, Bartek, Jiri
Format: Artigo
Langue:Inglês
Publié: Cold Spring Harbor Laboratory Press 2013
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3841735/
https://ncbi.nlm.nih.gov/pubmed/24240236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.224568.113
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