ATR–Chk1–APC/C(Cdh1)-dependent stabilization of Cdc7–ASK (Dbf4) kinase is required for DNA lesion bypass under replication stress

Cdc7 kinase regulates DNA replication. However, its role in DNA repair and recombination is poorly understood. Here we describe a pathway that stabilizes the human Cdc7–ASK (activator of S-phase kinase; also called Dbf4), its regulation, and its function in cellular responses to compromised DNA repl...

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Detalhes bibliográficos
Main Authors: Yamada, Masayuki, Watanabe, Kenji, Mistrik, Martin, Vesela, Eva, Protivankova, Iva, Mailand, Niels, Lee, MyungHee, Masai, Hisao, Lukas, Jiri, Bartek, Jiri
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2013
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3841735/
https://ncbi.nlm.nih.gov/pubmed/24240236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.224568.113
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