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ATR–Chk1–APC/C(Cdh1)-dependent stabilization of Cdc7–ASK (Dbf4) kinase is required for DNA lesion bypass under replication stress

Cdc7 kinase regulates DNA replication. However, its role in DNA repair and recombination is poorly understood. Here we describe a pathway that stabilizes the human Cdc7–ASK (activator of S-phase kinase; also called Dbf4), its regulation, and its function in cellular responses to compromised DNA repl...

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Autors principals: Yamada, Masayuki, Watanabe, Kenji, Mistrik, Martin, Vesela, Eva, Protivankova, Iva, Mailand, Niels, Lee, MyungHee, Masai, Hisao, Lukas, Jiri, Bartek, Jiri
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2013
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3841735/
https://ncbi.nlm.nih.gov/pubmed/24240236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.224568.113
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