Hyperphosphorylation of CDH1 in glioblastoma cancer stem cells attenuates APC/C(CDH1) activity and pharmacological inhibition of APC/C(CDH1/CDC20) compromises viability

Glioblastoma is the most common and lethal primary brain tumor and remains incurable. This is in part due to the cellular heterogeneity within these tumors which includes a subpopulation of treatment resistant cells called cancer stem-like cells (CSCs). We previously identified that the anaphase-pro...

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Dettagli Bibliografici
Pubblicato in:Mol Cancer Res
Autori principali: De, Kuntal, Grubb, Treg M, Zalenski, Abigail A, Pfaff, Kayla E, Pal, Debjani, Majumder, Shubhra, Summers, Matthew K, Venere, Monica
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7271747/
https://ncbi.nlm.nih.gov/pubmed/31036696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-18-1361
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