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Hyperphosphorylation of CDH1 in glioblastoma cancer stem cells attenuates APC/C(CDH1) activity and pharmacological inhibition of APC/C(CDH1/CDC20) compromises viability
Glioblastoma is the most common and lethal primary brain tumor and remains incurable. This is in part due to the cellular heterogeneity within these tumors which includes a subpopulation of treatment resistant cells called cancer stem-like cells (CSCs). We previously identified that the anaphase-pro...
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| Publicado no: | Mol Cancer Res |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7271747/ https://ncbi.nlm.nih.gov/pubmed/31036696 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-18-1361 |
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