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Molecular interactions involved in proton-dependent gating in KcsA potassium channels

The bacterial potassium channel KcsA is gated open by the binding of protons to amino acids on the intracellular side of the channel. We have identified, via channel mutagenesis and x-ray crystallography, two pH-sensing amino acids and a set of nearby residues involved in molecular interactions that...

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Detalles Bibliográficos
Main Authors: Posson, David J., Thompson, Ameer N., McCoy, Jason G., Nimigean, Crina M.
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2013
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3840921/
https://ncbi.nlm.nih.gov/pubmed/24218397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201311057
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