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Molecular mechanism of pH sensing in KcsA potassium channels

The bacterial potassium channel KcsA is gated by high concentrations of intracellular protons, allowing the channel to open at pH < 5.5. Despite prior attempts to determine the mechanism responsible for pH gating, the proton sensor has remained elusive. We have constructed a KcsA channel mutant t...

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Bibliographic Details
Main Authors: Thompson, Ameer N., Posson, David J., Parsa, Pirooz V., Nimigean, Crina M.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2008
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2383984/
https://ncbi.nlm.nih.gov/pubmed/18443286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0800873105
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