Engineering Folding Dynamics from Two-State to Downhill: Application to λ-Repressor

[Image: see text] One strategy for reaching the downhill folding regime, primarily exploited for the λ(6–85) protein fragment, consists of cumulatively introducing mutations that speed up folding. This is an experimentally demanding process where chemical intuition usually serves as a guide for the...

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Bibliografiske detaljer
Main Authors: Carter, James W., Baker, Christopher M., Best, Robert B., De Sancho, David
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2013
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3840902/
https://ncbi.nlm.nih.gov/pubmed/24079652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp405904g
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