Engineering Folding Dynamics from Two-State to Downhill: Application to λ-Repressor

[Image: see text] One strategy for reaching the downhill folding regime, primarily exploited for the λ(6–85) protein fragment, consists of cumulatively introducing mutations that speed up folding. This is an experimentally demanding process where chemical intuition usually serves as a guide for the...

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Bibliographic Details
Main Authors: Carter, James W., Baker, Christopher M., Best, Robert B., De Sancho, David
Format: Artigo
Language:Inglês
Published: American Chemical Society 2013
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3840902/
https://ncbi.nlm.nih.gov/pubmed/24079652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp405904g
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