CSF-1R inhibition alters macrophage polarization and blocks glioma progression

Glioblastoma multiforme (GBM) comprises several molecular subtypes including proneural GBM. Most therapeutic approaches targeting glioma cells have failed. An alternative strategy is to target cells in the glioma microenvironment, such as tumor-associated macrophages and microglia (TAMs). Macrophage...

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Main Authors: Pyonteck, Stephanie M., Akkari, Leila, Schuhmacher, Alberto J., Bowman, Robert L., Sevenich, Lisa, Quail, Daniela F., Olson, Oakley C., Quick, Marsha L., Huse, Jason T., Teijeiro, Virginia, Setty, Manu, Leslie, Christina S., Oei, Yoko, Pedraza, Alicia, Zhang, Jianan, Brennan, Cameron W., Sutton, James C., Holland, Eric C., Daniel, Dylan, Joyce, Johanna A.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3840724/
https://ncbi.nlm.nih.gov/pubmed/24056773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3337
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