The tumor microenvironment underlies acquired resistance to CSF1R inhibition in gliomas

Macrophages accumulate with glioblastoma multiforme (GBM) progression, and can be targeted via inhibition of colony stimulating factor-1 receptor (CSF-1R) to regress high-grade tumors in animal models of this cancer. However, whether and how resistance emerges in response to sustained CSF-1R blockad...

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Bibliografske podrobnosti
izdano v:Science
Main Authors: Quail, Daniela F., Bowman, Robert L., Akkari, Leila, Quick, Marsha L., Schuhmacher, Alberto J., Huse, Jason T., Holland, Eric C., Sutton, James C., Joyce, Johanna A.
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5450629/
https://ncbi.nlm.nih.gov/pubmed/27199435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aad3018
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