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The tumor microenvironment underlies acquired resistance to CSF1R inhibition in gliomas
Macrophages accumulate with glioblastoma multiforme (GBM) progression, and can be targeted via inhibition of colony stimulating factor-1 receptor (CSF-1R) to regress high-grade tumors in animal models of this cancer. However, whether and how resistance emerges in response to sustained CSF-1R blockad...
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| Publicado no: | Science |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5450629/ https://ncbi.nlm.nih.gov/pubmed/27199435 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aad3018 |
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