CSF-1R inhibition alters macrophage polarization and blocks glioma progression

Glioblastoma multiforme (GBM) comprises several molecular subtypes including proneural GBM. Most therapeutic approaches targeting glioma cells have failed. An alternative strategy is to target cells in the glioma microenvironment, such as tumor-associated macrophages and microglia (TAMs). Macrophage...

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Autors principals: Pyonteck, Stephanie M., Akkari, Leila, Schuhmacher, Alberto J., Bowman, Robert L., Sevenich, Lisa, Quail, Daniela F., Olson, Oakley C., Quick, Marsha L., Huse, Jason T., Teijeiro, Virginia, Setty, Manu, Leslie, Christina S., Oei, Yoko, Pedraza, Alicia, Zhang, Jianan, Brennan, Cameron W., Sutton, James C., Holland, Eric C., Daniel, Dylan, Joyce, Johanna A.
Format: Artigo
Idioma:Inglês
Publicat: 2013
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3840724/
https://ncbi.nlm.nih.gov/pubmed/24056773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3337
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