Visualization of local DNA unwinding by Mre11/Rad50/Nbs1 using single-molecule FRET

The Mre11/Rad50/Nbs1 (MRN) complex initiates and coordinates DNA repair and signaling events at double-strand breaks. The interaction between MRN and DNA ends is critical for the recruitment of DNA-processing enzymes, end tethering, and activation of the ATM protein kinase. Here we visualized MRN bi...

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Bibliografiska uppgifter
Huvudupphovsmän: Cannon, Brian, Kuhnlein, Jeffrey, Yang, Soo-Hyun, Cheng, Anita, Schindler, Detlev, Stark, Jeremy M., Russell, Rick, Paull, Tanya T.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2013
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3839711/
https://ncbi.nlm.nih.gov/pubmed/24191051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1309816110
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