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A DNA synthesis inhibitor is protective against proteotoxic stressors via modulation of fertility pathways in Caenorhabditis elegans

Loss of germline precursor cells in C. elegans has previously been shown to improve protein homeostasis and extend lifespan, possibly due to reallocation of resources to somatic cells. In contrast, mutants that are sterile simply due to loss of sperm or oocyte production have a normal lifespan, ofte...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Angeli, Suzanne, Klang, Ida, Sivapatham, Renuka, Mark, Karla, Zucker, David, Bhaumik, Dipa, Lithgow, Gordon J., Andersen, Julie K.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Impact Journals LLC 2013
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3838778/
https://ncbi.nlm.nih.gov/pubmed/24123581
Tagiau: Ychwanegu Tag
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