A DNA synthesis inhibitor is protective against proteotoxic stressors via modulation of fertility pathways in Caenorhabditis elegans

Loss of germline precursor cells in C. elegans has previously been shown to improve protein homeostasis and extend lifespan, possibly due to reallocation of resources to somatic cells. In contrast, mutants that are sterile simply due to loss of sperm or oocyte production have a normal lifespan, ofte...

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Autors principals: Angeli, Suzanne, Klang, Ida, Sivapatham, Renuka, Mark, Karla, Zucker, David, Bhaumik, Dipa, Lithgow, Gordon J., Andersen, Julie K.
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2013
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Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3838778/
https://ncbi.nlm.nih.gov/pubmed/24123581
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