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Chronic inhibition of cGMP-specific phosphodiesterase 5 suppresses endoplasmic reticulum stress in heart failure

BACKGROUND AND PURPOSE: Inhibition of the cGMP-specific phosphodiesterase 5 (PDE5) exerts profound beneficial effects on failing hearts. However, the mechanisms underlying the therapeutic effects of PDE5 inhibition on heart failure are unclear. The purpose of this study was to investigate whether PD...

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Autores principales: Gong, Wei, Duan, Quanlu, Cai, Zhejun, Chen, Chen, Ni, Li, Yan, Mengwen, Wang, Xingxu, Cianflone, Katherine, Wang, Dao Wen
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Publishing Ltd 2013
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3838686/
https://ncbi.nlm.nih.gov/pubmed/24032459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12346
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