Structural basis for ligase-specific conjugation of linear ubiquitin chains by HOIP

Linear ubiquitin chains are important regulators of cellular signaling pathways that control innate immunity and inflammation through NF-κB activation and protection against TNFα-induced apoptosis(1-5). They are synthesized by HOIP, which belongs to the RBR (RING-between-RING) family of E3 ligases a...

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Autori principali: Stieglitz, Benjamin, Rana, Rohini R., Koliopoulos, Marios G., Morris-Davies, Aylin C., Schaeffer, Veronique, Christodoulou, Evangelos, Howell, Steven, Brown, Nicholas R., Dikic, Ivan, Rittinger, Katrin
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3838313/
https://ncbi.nlm.nih.gov/pubmed/24141947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature12638
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