Fragment-Based Covalent Ligand Screening Enables Rapid Discovery of Inhibitors for the RBR E3 Ubiquitin Ligase HOIP

[Image: see text] Modification of proteins with polyubiquitin chains is a key regulatory mechanism to control cellular behavior and alterations in the ubiquitin system are linked to many diseases. Linear (M1-linked) polyubiquitin chains play pivotal roles in several cellular signaling pathways media...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Johansson, Henrik, Isabella Tsai, Yi-Chun, Fantom, Ken, Chung, Chun-Wa, Kümper, Sandra, Martino, Luigi, Thomas, Daniel A., Eberl, H. Christian, Muelbaier, Marcel, House, David, Rittinger, Katrin
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2019
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6383986/
https://ncbi.nlm.nih.gov/pubmed/30657686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b13193
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