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Fragment-Based Covalent Ligand Screening Enables Rapid Discovery of Inhibitors for the RBR E3 Ubiquitin Ligase HOIP
[Image: see text] Modification of proteins with polyubiquitin chains is a key regulatory mechanism to control cellular behavior and alterations in the ubiquitin system are linked to many diseases. Linear (M1-linked) polyubiquitin chains play pivotal roles in several cellular signaling pathways media...
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| Udgivet i: | J Am Chem Soc |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Chemical
Society
2019
|
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6383986/ https://ncbi.nlm.nih.gov/pubmed/30657686 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b13193 |
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