LUBAC synthesizes linear ubiquitin chains via a thioester intermediate

The linear ubiquitin chain assembly complex (LUBAC) is a RING E3 ligase that regulates immune and inflammatory signalling pathways. Unlike classical RING E3 ligases, LUBAC determines the type of ubiquitin chain being formed, an activity normally associated with the E2 enzyme. We show that the RING-i...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Stieglitz, Benjamin, Morris-Davies, Aylin C, Koliopoulos, Marios G, Christodoulou, Evangelos, Rittinger, Katrin
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2012
Pynciau:
Scientific Reports
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3432797/
https://ncbi.nlm.nih.gov/pubmed/22791023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2012.105
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