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LUBAC synthesizes linear ubiquitin chains via a thioester intermediate
The linear ubiquitin chain assembly complex (LUBAC) is a RING E3 ligase that regulates immune and inflammatory signalling pathways. Unlike classical RING E3 ligases, LUBAC determines the type of ubiquitin chain being formed, an activity normally associated with the E2 enzyme. We show that the RING-i...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3432797/ https://ncbi.nlm.nih.gov/pubmed/22791023 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2012.105 |
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