The FBXO4 Tumor Suppressor Functions as a Barrier to Braf(V600E)-Dependent Metastatic Melanoma

Cyclin D1–cyclin-dependent kinase 4/6 (CDK4/6) dysregulation is a major contributor to melanomagenesis. Clinical evidence has revealed that p16(INK4A), an allosteric inhibitor of CDK4/6, is inactivated in over half of human melanomas, and numerous animal models have demonstrated that p16(INK4A) dele...

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Main Authors: Lee, Eric K., Lian, Zhaorui, D'Andrea, Kurt, Letrero, Richard, Sheng, WeiQi, Liu, Shujing, Diehl, J. Nathaniel, Pytel, Dariusz, Barbash, Olena, Schuchter, Lynn, Amaravaradi, Ravi, Xu, Xiaowei, Herlyn, Meenhard, Nathanson, Katherine L., Diehl, J. Alan
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2013
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3838190/
https://ncbi.nlm.nih.gov/pubmed/24019069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00706-13
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