Increased cyclin D1 expression can mediate BRAF inhibitor resistance in BRAF V600E–mutated melanomas

Recent studies have shown that there is a considerable heterogeneity in the response of melanoma cell lines to MEK and BRAF inhibitors. In the current study, we address whether dysregulation of cyclin-dependent kinase 4 (CDK4) and/or cyclin D1 contribute to the BRAF inhibitor resistance of melanoma...

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Detalhes bibliográficos
Main Authors: Smalley, Keiran S.M., Lioni, Mercedes, Palma, Maurizia Dalla, Xiao, Min, Desai, Brijal, Egyhazi, Suzanne, Hansson, Johan, Wu, Hong, King, Alastair J., Van Belle, Patricia, Elder, David E., Flaherty, Keith T., Herlyn, Meenhard, Nathanson, Katherine L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2651569/
https://ncbi.nlm.nih.gov/pubmed/18790768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-08-0431
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