The Anti-Melanoma Activity of Dinaciclib, a Cyclin-Dependent Kinase Inhibitor, Is Dependent on p53 Signaling

Although cyclin dependent kinase (CDK)-2 is known to be dispensable for the growth of most tumors, it is thought to be important for the proliferation of melanoma cells, where its expression is controlled by the melanocyte-lineage specific transcription factor MITF. Treatment of a panel of melanoma...

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Detalhes bibliográficos
Main Authors: Desai, Brijal M., Villanueva, Jessie, Nguyen, Thierry-Thien K., Lioni, Mercedes, Xiao, Min, Kong, Jun, Krepler, Clemens, Vultur, Adina, Flaherty, Keith T., Nathanson, Katherine L., Smalley, Keiran S. M., Herlyn, Meenhard
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3601112/
https://ncbi.nlm.nih.gov/pubmed/23527225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0059588
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