MEK inhibition affects STAT3 signaling and invasion in human melanoma cell lines

Elevated activity of the MAPK signaling cascade is found in the majority of human melanomas and is known to regulate proliferation, survival, and invasion. Current targeted therapies focus on decreasing the activity of this pathway; however, we do not fully understand how these therapies impact tumo...

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Autors principals: Vultur, Adina, Villanueva, Jessie, Krepler, Clemens, Rajan, Geena, Chen, Quan, Xiao, Min, Li, Ling, Gimotty, Phyllis A., Wilson, Melissa, Hayden, James, Keeney, Frederick, Nathanson, Katherine L., Herlyn, Meenhard
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3769503/
https://ncbi.nlm.nih.gov/pubmed/23624919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.131
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