CRAF inhibition induces apoptosis in melanoma cells with non-V600E BRAF mutations

Here we identify a panel of melanoma lines with non-V600E mutations in BRAF. These G469E and D594G-mutated melanomas were found to exhibit constitutive levels of pERK, low levels of pMEK and were resistant to MEK inhibition. Upon treatment with the CRAF inhibitor sorafenib, these lines underwent apo...

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Detalhes bibliográficos
Main Authors: Smalley, Keiran S. M., Xiao, Min, Villanueva, Jessie, Nguyen, Thiennga K, Flaherty, Keith T., Letrero, Richard, Belle, Patricia Van, Elder, David E., Wang, Yan, Nathanson, Katherine L., Herlyn, Meenhard
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2898184/
https://ncbi.nlm.nih.gov/pubmed/18794803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2008.362
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