Thioridazine Pharmacokinetic-Pharmacodynamic Parameters “Wobble” during Treatment of Tuberculosis: a Theoretical Basis for Shorter-Duration Curative Monotherapy with Congeners

Phenothiazines are being repurposed for treatment of tuberculosis. We examined time-kill curves of thioridazine and first-line drugs against log-growth-phase and semidormant bacilli under acidic conditions and nonreplicating persistent Mycobacterium tuberculosis. While both the potency and the effic...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Musuka, Sandirai, Srivastava, Shashikant, Siyambalapitiyage Dona, Chandima Wasana, Meek, Claudia, Leff, Richard, Pasipanodya, Jotam, Gumbo, Tawanda
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2013
Témata:
Experimental Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3837896/
https://ncbi.nlm.nih.gov/pubmed/24041886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00829-13
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky