Thioridazine Pharmacokinetic-Pharmacodynamic Parameters “Wobble” during Treatment of Tuberculosis: a Theoretical Basis for Shorter-Duration Curative Monotherapy with Congeners

Phenothiazines are being repurposed for treatment of tuberculosis. We examined time-kill curves of thioridazine and first-line drugs against log-growth-phase and semidormant bacilli under acidic conditions and nonreplicating persistent Mycobacterium tuberculosis. While both the potency and the effic...

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Detalhes bibliográficos
Main Authors: Musuka, Sandirai, Srivastava, Shashikant, Siyambalapitiyage Dona, Chandima Wasana, Meek, Claudia, Leff, Richard, Pasipanodya, Jotam, Gumbo, Tawanda
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3837896/
https://ncbi.nlm.nih.gov/pubmed/24041886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00829-13
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