In Vitro Phenotypic Characterization of Hepatitis C Virus NS3 Protease Variants Observed in Clinical Studies of Telaprevir

Telaprevir is a linear, peptidomimetic small molecule that inhibits hepatitis C virus (HCV) replication by specifically inhibiting the NS3·4A protease. In phase 3 clinical studies, telaprevir in combination with peginterferon and ribavirin (PR) significantly improved sustained virologic response (SV...

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Bibliografiske detaljer
Main Authors: Jiang, Min, Mani, Nagraj, Lin, Chao, Ardzinski, Andrzej, Nelson, Michelle, Reagan, Dugan, Bartels, Doug, Zhou, Yi, Nicolas, Olivier, Rao, B. Govinda, Müh, Ute, Hanzelka, Brian, Tigges, Ann, Rijnbrand, Rene, Kieffer, Tara L.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2013
Fag:
Antiviral Agents
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3837892/
https://ncbi.nlm.nih.gov/pubmed/24100495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01578-13
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