Carregant...

The Allosteric Mechanism of Activation of Antithrombin as an Inhibitor of Factor IXa and Factor Xa: HEPARIN-INDEPENDENT FULL ACTIVATION THROUGH MUTATIONS ADJACENT TO HELIX D

Allosteric conformational changes in antithrombin induced by binding a specific heparin pentasaccharide result in very large increases in the rates of inhibition of factors IXa and Xa but not of thrombin. These are accompanied by CD, fluorescence, and NMR spectroscopic changes. X-ray structures show...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Dementiev, Alexey, Swanson, Richard, Roth, Ryan, Isetti, Giulia, Izaguirre, Gonzalo, Olson, Steven T., Gettins, Peter G. W.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2013
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3837108/
https://ncbi.nlm.nih.gov/pubmed/24068708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.510727
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!