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The novel HSP90 inhibitor STA-9090 exhibits activity against Kit-dependent and -independent malignant mast cell tumors

OBJECTIVE: Mutations of the receptor tyrosine kinase Kit occur in several human and canine cancers. While Kit inhibitors have activity in the clinical setting, they possess variable efficacy against particular forms of mutant Kit and drug resistance often develops over time. Inhibitors of heat shock...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Lin, Tzu-Yin, Bear, Misty, Du, Zhenjian, Foley, Kevin P., Ying, Weiwen, Barsoum, James, London, Cheryl
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2008
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3837096/
https://ncbi.nlm.nih.gov/pubmed/18657349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2008.05.001
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