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The novel HSP90 inhibitor STA-9090 exhibits activity against Kit-dependent and -independent malignant mast cell tumors

OBJECTIVE: Mutations of the receptor tyrosine kinase Kit occur in several human and canine cancers. While Kit inhibitors have activity in the clinical setting, they possess variable efficacy against particular forms of mutant Kit and drug resistance often develops over time. Inhibitors of heat shock...

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Autors principals: Lin, Tzu-Yin, Bear, Misty, Du, Zhenjian, Foley, Kevin P., Ying, Weiwen, Barsoum, James, London, Cheryl
Format: Artigo
Idioma:Inglês
Publicat: 2008
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3837096/
https://ncbi.nlm.nih.gov/pubmed/18657349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2008.05.001
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