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Stage specific reprogramming of mouse embryo liver cells to a beta cell-like phenotype
We show that cultures of mouse embryo liver generate insulin-positive cells when transduced with an adenoviral vector encoding the three genes: Pdx1, Ngn3 and MafA (Ad-PNM). Only a proportion of transduced cells become insulin-positive and the highest yield occurs in the period E14-16, declining at...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3836862/ https://ncbi.nlm.nih.gov/pubmed/23994012 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mod.2013.08.002 |
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