Hepatic Basolateral Efflux Contributes Significantly to Rosuvastatin Disposition I: Characterization of Basolateral Versus Biliary Clearance Using a Novel Protocol in Sandwich-Cultured Hepatocytes

Transporters responsible for hepatic uptake and biliary clearance (CL(Bile)) of rosuvastatin (RSV) have been well characterized. However, the contribution of basolateral efflux clearance (CL(BL)) to hepatic and systemic exposure of RSV is unknown. Additionally, the appropriate design of in vitro hep...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Pfeifer, Nathan D., Yang, Kyunghee, Brouwer, Kim L. R.
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Pharmacology and Experimental Therapeutics 2013
Témata:
Metabolism, Transport, and Pharmacogenomics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3836307/
https://ncbi.nlm.nih.gov/pubmed/24023367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.113.207472
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky