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A winged helix domain in human MUS81 binds DNA and modulates the endonuclease activity of MUS81 complexes
The MUS81-EME1 endonuclease maintains metazoan genomic integrity by cleaving branched DNA structures that arise during the resolution of recombination intermediates. In humans, MUS81 also forms a poorly characterized complex with EME2. Here, we identify and determine the structure of a winged helix...
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| 主要な著者: | , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Oxford University Press
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3834828/ https://ncbi.nlm.nih.gov/pubmed/23982516 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt760 |
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