A winged helix domain in human MUS81 binds DNA and modulates the endonuclease activity of MUS81 complexes

The MUS81-EME1 endonuclease maintains metazoan genomic integrity by cleaving branched DNA structures that arise during the resolution of recombination intermediates. In humans, MUS81 also forms a poorly characterized complex with EME2. Here, we identify and determine the structure of a winged helix...

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Autores principales: Fadden, Andrew J., Schalbetter, Stephanie, Bowles, Maureen, Harris, Richard, Lally, John, Carr, Antony M., McDonald, Neil Q.
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2013
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3834828/
https://ncbi.nlm.nih.gov/pubmed/23982516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt760
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