Fasudil, a rho kinase inhibitor, limits motor neuron loss in experimental models of amyotrophic lateral sclerosis

BACKGROUND AND PURPOSE: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder with no effective treatment. Fasudil hydrochloride (fasudil), a potent rho kinase (ROCK) inhibitor, is useful for the treatment of ischaemic diseases. In previous reports, fasudil improved pathology in...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Takata, M, Tanaka, H, Kimura, M, Nagahara, Y, Tanaka, K, Kawasaki, K, Seto, M, Tsuruma, K, Shimazawa, M, Hara, H
Format: Artigo
Langue:Inglês
Publié: Blackwell Publishing Ltd 2013
Sujets:
Research Papers
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3834758/
https://ncbi.nlm.nih.gov/pubmed/23763343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12277
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