Activation of K(Ca)3.1 by SKA-31 induces arteriolar dilatation and lowers blood pressure in normo- and hypertensive connexin40-deficient mice

BACKGROUND AND PURPOSE: The calcium-activated potassium channel K(Ca)3.1 is expressed in the vascular endothelium where its activation causes endothelial hyperpolarization and initiates endothelium-derived hyperpolarization (EDH)-dependent dilatation. Here, we investigated whether pharmacological ac...

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Detalhes bibliográficos
Main Authors: Radtke, Josephine, Schmidt, Kjestine, Wulff, Heike, Köhler, Ralf, Wit, Cor
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2013
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3834754/
https://ncbi.nlm.nih.gov/pubmed/23734697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12267
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