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SKA-31, a novel activator of SK(Ca) and IK(Ca) channels, increases coronary flow in male and female rat hearts

AIMS: Endothelial SK(Ca) and IK(Ca) channels play an important role in the regulation of vascular function and systemic blood pressure. Based on our previous findings that small molecule activators of SK(Ca) and IK(Ca) channels (i.e. NS309 and SKA-31) can inhibit myogenic tone in isolated resistance...

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Detalles Bibliográficos
Main Authors: Mishra, Ramesh C., Belke, Darrell, Wulff, Heike, Braun, Andrew P.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2013
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3543990/
https://ncbi.nlm.nih.gov/pubmed/23118129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvs326
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