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Simultaneous knock-down of Bcl-xL and Mcl-1 induces apoptosis through Bax activation in pancreatic cancer cells

Anti-apoptotic Bcl-2 family proteins have been reported to play an important role in apoptotic cell death of human malignancies. The aim of this study was to delineate the mechanism of anti-apoptotic Bcl-2 family proteins in pancreatic cancer (PaCa) cell survival. We first analyzed the endogenous ex...

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Autores principales: Takahashi, Hiroki, Chen, Monica C., Pham, Hung, Matsuo, Yoichi, Ishiguro, Hideyuki, Reber, Howard A., Takeyama, Hiromitsu, Hines, Oscar J., Eibl, Guido
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3834082/
https://ncbi.nlm.nih.gov/pubmed/23954445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamcr.2013.08.006
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