Biochemical determinants of tumor sensitivity to 5-fluorouracil: Ultrasensitive methods for the determination of 5-fluoro-2′-deoxyuridylate, 2′-deoxyuridylate, and thymidylate synthetase

Techniques have been developed to measure FdUMP, the active metabolite of 5-FUra; thymidylate synthetase (TMP synthase; 5,10-methylenetetrahydrofolate:dUMP C-methyltransferase, EC 2.1.1.45), the target enzyme for this antimetabolite; and dUMP, the substrate that competes with FdUMP for binding to TM...

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Hlavní autoři: Moran, Richard G., Spears, C. Paul, Heidelberger, Charles
Médium: Artigo
Jazyk:Inglês
Vydáno: 1979
Témata:
Biological Sciences: Medical Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC383271/
https://ncbi.nlm.nih.gov/pubmed/108681
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