Amplification of Thymidylate Synthetase in Metastatic Colorectal Cancer Patients Pretreated with 5-Fluorouracil-based Chemotherapy

Resistance to 5-fluorouracil (5-FU) represents a major contributor to cancer-related mortality in advanced colorectal cancer patients. Genetic variations and expression alterations in genes involved in 5-FU metabolism and effect have been shown to modulate 5-FU sensitivity in vitro, however these al...

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Main Authors: Watson, Roshawn G, Muhale, Filipe, Thorne, Leigh B, Yu, Jinsheng, O'Neil, Bert H, Hoskins, Janelle M, Meyers, Michael O, Deal, Allison M, Ibrahim, Joseph G, Hudson, Michael L, Walko, Christine M, McLeod, Howard L, Auman, James T
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2991554/
https://ncbi.nlm.nih.gov/pubmed/20727737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejca.2010.07.011
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