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Mechanism-based inhibitors of thymidylate synthetase
An early event in the catalytic mechanism of thymidylate synthetase involves attack at the 6-position of the substrate 2′-deoxyuridylate by a nucleophile of the enzyme to form a 5,6-dihydropyrimidine intermediate which remains covalently bound to the enzyme throughout the catalytic sequence. A numbe...
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| Publicado no: | Nucleic Acids Res |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
1978
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6581308/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/1.suppl_2.s423 |
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