Correlation of thymidylate synthase, thymidine phosphorylase and dihydropyrimidine dehydrogenase with sensitivity of gastrointestinal cancer cells to 5-fluorouracil and 5-fluoro-2’-deoxyuridine

AIM: To determine the expression levels of three metabolic enzymes of fluoropyrimidines: thymidylate synthase (TS), thymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD) in seven human gastrointestinal cancer cell lines, and to compare the enzyme levels with the sensitivity to 5-flu...

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Detalhes bibliográficos
Publicado no:World J Gastroenterol
Main Authors: Ma, Tao, Zhu, Zheng-Gang, Ji, Yu-Bao, Zhang, Yi, Yu, Ying-Yan, Liu, Bing-Ya, Yin, Hao-Ran, Lin, Yan-Zhen
Formato: Artigo
Idioma:Inglês
Publicado em: Baishideng Publishing Group Inc 2004
Assuntos:
Gastric Cancer
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4716997/
https://ncbi.nlm.nih.gov/pubmed/14716816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.v10.i2.172
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